Hiroyuki Koide Selected Research

alanyl-prolyl-arginyl-prolyl-glycine

5/2014	Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499.
3/2011	Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.
1/2011	Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector.

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Hiroyuki Koide Research Topics

Disease

16	Neoplasms (Cancer) 01/2021 - 01/2008
4	Melanoma (Melanoma, Malignant) 01/2015 - 03/2008
3	Brain Ischemia (Cerebral Ischemia) 12/2019 - 01/2016
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/2019 - 01/2016
3	Ischemic Stroke 01/2017 - 01/2016
3	Neoplasm Metastasis (Metastasis) 01/2012 - 03/2008
2	Hemolysis 01/2021 - 07/2020
2	Hyperglycemia 01/2021 - 01/2019
2	Sepsis (Septicemia) 01/2021 - 12/2017
2	Reperfusion Injury 12/2019 - 06/2016
2	Carcinoma (Carcinomatosis) 01/2018 - 03/2011
2	Ischemia 01/2017 - 02/2009
1	Nervous System Diseases (Neurological Disorders) 01/2020
1	Amyloidosis 01/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Chronic Renal Insufficiency 01/2019
1	Triple Negative Breast Neoplasms 01/2018
1	Stroke (Strokes) 01/2017
1	Cerebral Hemorrhage 01/2017
1	Infections 01/2017
1	Necrosis 01/2017
1	Thrombosis (Thrombus) 01/2017
1	Cerebral Infarction 01/2016
1	Experimental Melanoma 01/2012
1	Sarcoma (Soft Tissue Sarcoma) 01/2012
1	Fibrosarcoma 03/2011

Drug/Important Bio-Agent (IBA)

9	Small Interfering RNA (siRNA)IBA 07/2020 - 01/2011
5	Triethylenephosphoramide (TEPA)IBA 01/2015 - 01/2011
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2012
3	PolymersIBA 01/2021 - 01/2019
3	Liposomes (Liposome)IBA 12/2019 - 03/2011
3	Proteins (Proteins, Gene)FDA Link 10/2019 - 05/2014
3	Neuroprotective AgentsIBA 01/2017 - 01/2016
3	alanyl-prolyl-arginyl-prolyl-glycineIBA 05/2014 - 01/2011
2	Histones (Histone)IBA 01/2021 - 12/2017
2	HydrogelsIBA 01/2021 - 10/2019
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2012
2	fasudil (AT 877)IBA 01/2017 - 06/2016
2	Therapeutic UsesIBA 01/2016 - 05/2014
2	TOR Serine-Threonine KinasesIBA 01/2015 - 01/2011
2	Peptides (Polypeptides)IBA 03/2011 - 01/2011
1	CarbohydratesIBA 01/2021
1	Melitten (Melittin)IBA 01/2021
1	poly-N-isopropylacrylamideIBA 01/2021
1	Biological ProductsIBA 07/2020
1	ClathrinIBA 07/2020
1	Prealbumin (Transthyretin)IBA 01/2020
1	patisiranIBA 01/2020
1	ifenprodilIBA 12/2019
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2019
1	Indicators and Reagents (Reagents)IBA 10/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2019
1	diethylenetriamineIBA 01/2019
1	dioleoyl phosphateIBA 01/2019
1	DEET (DET)IBA 01/2019
1	MorpholinosIBA 01/2019
1	Insulin (Novolin)FDA Link 01/2019
1	indoleIBA 01/2019
1	Epidermal Growth Factor (EGF)IBA 01/2018
1	Lipid NanoparticlesIBA 01/2018
1	Polo-Like Kinase 1IBA 01/2018
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2018
1	Radioisotopes (Radionuclides)IBA 01/2018
1	N-isopropylacrylamideIBA 12/2017
1	Matrix Metalloproteinases (MMPs)IBA 01/2017
1	InterferonsIBA 01/2017
1	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2017
1	Messenger RNA (mRNA)IBA 01/2017
1	rho-Associated KinasesIBA 06/2016
1	Tacrolimus (Prograf)FDA LinkGeneric 01/2016
1	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/2016
1	Sirolimus (Rapamycin)FDA Link 01/2015
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 05/2014
1	EstersIBA 01/2012
1	rhinacanthin-NIBA 01/2012
1	NaphthoquinonesIBA 01/2012
1	arginyl-glycyl-aspartic acidIBA 01/2012
1	CholesterolIBA 03/2011
1	LuciferasesIBA 03/2011
1	Mechanistic Target of Rapamycin Complex 2IBA 01/2011
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 01/2011
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2011
1	Oxygen (Dioxygen)IBA 02/2009
1	gamma-sitosterol (beta-sitosterol)IBA 03/2008
1	Phosphatidylcholines (Phosphatidylcholine)IBA 03/2008
1	Immunologic Factors (Immunomodulators)IBA 01/2008
1	PicibanilIBA 01/2008

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2011
5	Intravenous Injections 01/2021 - 05/2014
1	Thrombolytic Therapy 01/2017
1	Intravenous Administration 06/2016
1	Drug Therapy (Chemotherapy) 01/2012
1	Chemoprevention 03/2008
1	Immunotherapy 01/2008